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KMID : 0369819940240010033
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Jorunal of Korean Pharmaceutical Sciences
1994 Volume.24 No. 1 p.33 ~ p.40
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A Formulation Study on the Combined Preparation of Nitroxynil and Levamisole for Subcutaneous Injection
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오순균/Oh SG
오경희/김종국/Oh KH/Kim CK
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Abstract
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In order to develop a broad-spectrum veterinary anthelmintic, a combined preparation of nitroxynil and levamisole was formulated for subcutaneous injection. The preformulation studies on solubilization, physicochemical stability and toxicity of combined preparation were performed. The combined preparation of nitroxynil-N-ethylglucamine and levamisole base could be solubilized up to 50.3%(w/v) of active ingredient concentration in propylene glycol/water system. Injectable solutions were most stable at 4?C. Local toxicities such as flare and edema were not shown when the usual dose of the combined preparation was injected subcutaneously to the rats.
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KEYWORD
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Combined preparation, Nitroxynil, Levamisole, Propylene glycol, N-Ethylglucamine, Veterinary anthelmintic
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